The shop at Lewes House on the High Street will be open from 15 October.
The annual pop-up shop will be run by volunteers until 17 December, with a wide range of cards and gifts - all raising money for local and national charities.
The charity aims to raise a total of £500,000 across the country this Christmas, to support more than 70 charities
Cars for Good Causes is a charity which has operated for more than 60 years. Supported charities include Diabetes UK, RNLI, British Heart Foundation, Alzheimers UK, Epilepsy UK, MS Society and a host of local charities.
The Shop Manager at Lewes ays: "We can't wait to meet everyone this year in our shop! Please come volunteer with us, or come and get your Christmas gifts whilst supporting the charities of your choice. I wish everyone a very festive Christmas and hope to see you soon!"
Find more details about the charity and a list of all stores on their website.
Mum of boy killed by scaffold plank backs annual road safety operation
Unsafe farm buildings at Knights Farm West to be demolished
Wealden Community Sports Hub provides opportunities for women, girls and grassroots sport
Reaction to Local Government Reorganisation pause
Police called to reports of a stabbing in Eastbourne
Former primary school teacher jailed for child sex offences
Twelve friends, 50km across the South Downs, 11 workouts, in memory of two little girls
Police carry out speeding checks on Friday Street in Eastbourne amid dangerous driving concerns