The Christmas Cards, which show a variety of well known local scenes have been designed by artist Lyndsey Smith.
Designs include Eastbourne Bandstand, the village of Hurstpierpoint, ice skaters at Brighton's Royal Pavilion and snowmen on the railway land near Lewes.
Sales of the cards are raising money for SASBAH - the Sussex Association for Spina Bifida and Hydrocephalus, who are based at Gun Hill near Horam.
Rom Sanglaji, CEO at SASBAH, said: "We are very grateful to Lyndsey for her amazing work. The cards really capture the beauty of Sussex and funds raised this year will make a real difference to our charity."
A pack of 10 cards costs £4 and can be ordered by emailing firstname.lastname@example.org