Industrial action by ASLEF means that no Southern, Thameslink or Gatwick Express services will run.
Additionally, services will again be limited on Saturday 13 May, with trains starting later in the day and final trains expected to be much earlier.
Due to overtime bans, an amended timetable is expected across the local area from Monday 15 to Saturday 20 May.
Currently, further strike dates are planned for Wednesday 31 May and Saturday 3 June, where again there will be no trains running.