Industrial action by ASLEF means that no Southern, Thameslink or Gatwick Express services will run.
Additionally, services will again be limited on Saturday 13 May, with trains starting later in the day and final trains expected to be much earlier.
Due to overtime bans, an amended timetable is expected across the local area from Monday 15 to Saturday 20 May.
Currently, further strike dates are planned for Wednesday 31 May and Saturday 3 June, where again there will be no trains running.
Flooding forces Eastbourne roller-skating rink to close
£50,000 fundraising goal set for 'significant' Arlington Stadium repairs
Hailsham main road to remain closed for further five weeks as works move to second phase
Eastbourne MP to meet with new South East Water CEO to discuss 'ongoing challenges'
South East Water looking to repair leak in Eastbourne road ‘as soon as possible’
East Hoathly Care Home Named in Care Experts UK Top 10
Eastbourne man, 23, jailed for running Brighton drugs line
Fourth member of family pulled from the water in Shoreham sadly dies